• Judy C Boughey, Farzin Goravanchi, Ronald N Parris, Spencer S Kee, Alicia M Kowalski, John C Frenzel, Isabelle Bedrosian, Funda Meric-Bernstam, Kelly K Hunt, Frederick C Ames, Henry M Kuerer, and Anthony Lucci.
• Department of Surgery, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
• Am. J. Surg. 2009 Nov 1;198(5):720-5.

BackgroundThe goal of the current study was to evaluate the effect of regional anesthesia using paravertebral block (PVB) on postoperative pain after breast surgery.MethodsPatients undergoing unilateral breast surgery without reconstruction were randomized to general anesthesia (GA) only or PVB with GA and pain scores assessed.ResultsEighty patients were randomized (41 to GA and 39 to PVB with GA). Operative times were not significantly different between groups. Pain scores were lower after PVB compared to GA at 1 hour (1 vs 3, P = .006) and 3 hours (0 vs 2, P = .001) but not at later time points. The overall worst pain experienced was lower with PVB (3 vs 5, P = .02). More patients were pain-free in the PVB group at 1 hour (44% vs 17%, P = .014) and 3 hours (54% vs 17%, P = .005) postoperatively.ConclusionsPVB significantly decreases postoperative pain up to 3 hours after breast cancer surgery.

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