• Pol. Merkur. Lekarski · Apr 2007

    Editorial

    [Genetic background of sarcoidosis].

    • Agata Krawczyk.
    • Pol. Merkur. Lekarski. 2007 Apr 1;22(130):243-8.

    AbstractSarcoidosis is a multisystemic disease of unknown pathogenesis. Its characteristic feature is formation of noncaseating granuloma in involved organs. The current etiologic hypothesis suggests that an unknown antigen/ agent might promote granuloma formation in hosts genetically susceptible to Th1 - response. The network of interactions between immunocompetent cells (mainly Th1-lymphocytes and macrophages) and the influence of many cytokines and chemokines lead to the sarcoid granuloma formation. The variations in prevalence and incidence of this disease in individuals from different ethnic, racial groups or families show, that the genetic factors are also involved in sarcoidosis etiology. Although there is a clear genetic influence on the risk of sarcoidosis, the relation between clinical course of the disease is an area for further exploration in the future.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…