• Mar Drugs · Feb 2014

    Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.

    • Gregory A Ellis, Thomas P Wyche, Charles G Fry, Doug R Braun, and Tim S Bugni.
    • Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. gaellis@wisc.edu.
    • Mar Drugs. 2014 Feb 1;12(2):1013-22.

    AbstractTwo novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-¹³C glucose, and analysis of a ¹³C-¹³C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).

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