• Hong Zhang and Xin-min Wu.
• Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing 100034, China.
• Zhonghua Yi Xue Za Zhi. 2009 Mar 24;89(11):758-62.

ObjectiveTo investigate the incidence and influential factors of post-operative nausea and vomiting (PONV) following gynecologic surgery so as to provide guideline effective for clinical management.MethodsThe clinical data of 492 qualified consecutive female patients who had undergone gynecological surgery were analyzed. Univariate analysis and multivariate logistic regression were applied to examine the relations between the perioperative variables and occurrence of PONV within 6 h or 24 h following gynecologic procedures.ResultsPONV developed in 218 patients within 24 h following surgery (44.3%) while in 161 patients within 6 h following surgery (32.7%). Multivariate logistic regression analysis identified PONV history and perioperative opioids administration as significant predictors of PONV within 24 h following gynecologic surgery, while PONV history, general anesthesia, and postoperative shivering predictors of PONV within 6 h after surgery, and found the administration of dexamethasone or droperidol as consistent protective factors of PONV within 6 h or 24 h following surgery.ConclusionFor gynecologic surgery, previous PONV history will increase the risk for PONV following current surgery. Perioperative opioids administration will intensify the risk for the development of PONV within 24 h following surgery, while general anesthesia and postoperative shivering for PONV within 6 h after surgery. Perioperative dexamethasone or droperidol will decrease the incidence of PONV within 6 h or 24 h following gynecologic procedures.

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