• Qi-ping Wang, Shi-ming Zhang, Heng Gao, Han-rong Na, Yu Xu, Jun Xu, and Lei Yang.
• Department of Neurosurgery, Jiangyin People's Hospital, Jiangyin 214400, China.
• Zhonghua Yi Xue Za Zhi. 2013 Jun 18;93(23):1784-7.

ObjectiveTo elucidate the effectiveness of brain tissue oxygenation (PbtO2) plus intracranial pressure (ICP) monitoring and targeted therapy in patients of severe traumatic brain injury (TBI).MethodsA total of 46 patients with severe TBI (Glasgow coma scale, GCS scale ≤ 8) admitted at Jiangyin People's Hospital from June 2009 to June 2012 were divided randomly into 2 groups and evaluated prospectively.Patients undergoing ICP plus PbtO2 monitoring were compared with controls with ICP monitoring alone.Therapies of both patient groups were attempted to maintain an ICP < 20 mm Hg and a cerebral perfusion pressure (CPP) ≥ 60 mm Hg.Among those with PbtO2 monitoring, oxygenation was maintained at a level of ≥ 20 mm Hg.The scores of Glasgow outcome scale (GOS) were compared between two groups at Month 6 post-injury.ResultsThe mean daily ICP and CPP levels were similar in each group.The mortality rate was 21.7% in patients with ICP monitoring alone and the favorable outcome rate was 47.8%.However, those receiving combined management had a significantly reduced mortality rate of 8.7% and good outcome rate of 65.2% (P < 0.05).ConclusionThe combined use of both ICP and PbtO2 may be associated with reduced mortality and improved outcome in patients with severe TBI.

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