• Anna Maria Ierardi, Natalie Lucchina, Mario Petrillo, Chiara Floridi, Filippo Piacentino, Alessandro Bacuzzi, Paolo Fonio, Federico Fontana, Carlo Fugazzola, Luca Brunese, and Gianpaolo Carrafiello.
• Department of Radiology, Interventional Radiology, Insubria University, Viale Borri, 57, 21100, Varese, Italy.
• Radiol Med. 2014 Jul 1;119(7):483-98.

AbstractUnresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis. Ablation techniques are based on direct application of chemical, thermal, or electrical energy to a tumor, which leads to cellular necrosis. Initial studies about ablation therapies of the pancreas were associated with significant morbidity and mortality, which limited widespread adoption. Modifications to the various applications, in particular combining the techniques with high-quality imaging and intra-operative approach has enabled real-time treatment monitoring and significant improvements in safety. Inoperable cases of pancreatic cancer have been treated by various ablation techniques in the last few years with promising results. The purpose of this review is to present the current status of local ablative therapies in the treatment of pancreatic advanced tumor.

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