• Pediatr Hematol Oncol · Oct 2013

    Case Reports

    Voriconazole induced bradycardia.

    • Dilek Uludağ, Nihal Ozdemir, Gülen Tüysüz, Ayşe Güler Eroğlu, and Tiraje Celkan.
    • 1Department of Pediatric Hematology-Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    • Pediatr Hematol Oncol. 2013 Oct 1;30(7):674-6.

    AbstractVoriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.

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