• J Pain Symptom Manage · Jun 1990

    Review

    Pharmacology of spinal opioids.

    • M B Sabbe and T L Yaksh.
    • J Pain Symptom Manage. 1990 Jun 1;5(3):191-203.

    AbstractThis review presents the pharmacology of spinal opioid receptor systems which are primarily involved in pain processing. The major areas upon which we will focus are: the structure and cellular functioning of the opioid receptor systems; the physiologic effects induced by spinally administered opioids, particularly in pain modulation; and pharmacokinetic and dynamic considerations, with special attention to the problem of opioid tolerance development.

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