[Tranexamic acid therapy decreases mortality of traumatic

Medicina intensiva · Jun 2011

[Tranexamic acid therapy decreases mortality of traumatic hemorrhagic shock].

The CRASH 2, a randomized, double-blind, controlled trial, that enrolled 20,211 adult trauma patients, has shown that the administration of tranexamic acid significantly reduces all-cause mortality and that specifically associated with severe blood loss as well. We consider it a significant therapeutic advance, because, for the first time, a drug has been demonstrated to safely diminish mortality due to traumatic bleeding shock. On the basis of these results, and the high rate of death due to traumatic bleeding, we suggest that tranexamic acid should be considered for compassionate use in bleeding trauma patients prior to its definitive approval for this medical condition.

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- A Muñoz-Sánchez and F Murillo-Cabezas.
- Cuidados Críticos y Urgencias, Hospital Universitario Virgen del Rocío, Sevilla, España. angeles.munoz.sspa@juntadeandalucia.es
- Med Intensiva. 2011 Jun 1;35(5):286-7.
AbstractThe CRASH 2, a randomized, double-blind, controlled trial, that enrolled 20,211 adult trauma patients, has shown that the administration of tranexamic acid significantly reduces all-cause mortality and that specifically associated with severe blood loss as well. We consider it a significant therapeutic advance, because, for the first time, a drug has been demonstrated to safely diminish mortality due to traumatic bleeding shock. On the basis of these results, and the high rate of death due to traumatic bleeding, we suggest that tranexamic acid should be considered for compassionate use in bleeding trauma patients prior to its definitive approval for this medical condition.Copyright © 2011 Elsevier España, S.L. y SEMICYUC. All rights reserved.

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[Tranexamic acid therapy decreases mortality of traumatic hemorrhagic shock].

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