• Ugeskrift for laeger · Apr 2012

    Case Reports

    [The clinical course of a three year-old girl after overdose of valproic acid].

    • Thalia Marie Blicher, Esben Thyssen Vestergaard, and Kim Peder Dalhoff.
    • Klinisk Farmakologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark. thalia@dadlnet.dk
    • Ugeskr. Laeg. 2012 Apr 23;174(17):1165-6.

    AbstractValproic acid (VA) is an antiepileptic drug, and frequently prescribed in pediatrics. VA overdose results in central nervous system depression, insufficient respiration, tachycardia, hypotension, hepatotoxicity, and electrolyte derangement. We describe the clinical course of a three year-old girl after accidental intake of 6,000 mg VA. Treatment included activated charcoal. Clinical observation included measurements of blood pressure, cardiac telemetry, and measurements of serum VA and metabolic parameters every 4-6 hrs. The girl was discharged successfully after 72 hrs with her usual dose of VA.

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