• Chi-Yung Yeung, Kun-Ting Hong, Chien-Ping Chiang, Yuan-Hao Chen, Hsin-I Ma, and Tung-Hang Tsai.
• Department of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
• World Neurosurg. 2016 Apr 1; 88: 688.e13-688.e16.

BackgroundAnaplastic large cell lymphoma (ALCL) is a malignant non-Hodgkin lymphoma, typically associated with anaplastic lymphoma kinase (ALK) expression. In some cases, lack of ALK translocation correlated with a more unfavorable prognosis.Case DescriptionWe describe a case of ALK(-) ALCL that manifested as a progressive, enlarged, swollen mass on the scalp after an acute head injury in an 84-year-old man. Neither palpable lymph nodes nor any B symptoms were noted on admission. Brain computed tomography showed a hematoma in the right posterior occipital region of the scalp as the only remarkable finding. Débridement and biopsy were performed. Histologic and immunohistochemical analysis of the specimen revealed an ALK(-) ALCL of the scalp. The lymphoma was resistant to bendamustine-containing chemotherapies, ultimately leading to the patient's death within 2 months.ConclusionsThis case report highlights the importance of recognizing the possibility of an ALCL manifesting as a focal inflammatory swelling mass on the scalp.Copyright © 2016 Elsevier Inc. All rights reserved.

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