• A C Van Elstraete, F Pastureau, T Lebrun, and H Mehdaoui.
• Department of Anaesthesiology, Saint-Paul Medical Center, University Hospital, Fort-de-France, Martinique, France.
• Eur J Anaesthesiol. 2001 Apr 1;18(4):257-60.

Background And ObjectiveWe have assessed the analgesic efficacy and side-effects of neostigmine when added to lidocaine for axillary brachial plexus block, in a prospective, randomized, double-blind, placebo-controlled study.MethodsWe studied 34 ASA I or II patients undergoing elective ambulatory carpal tunnel release. Axillary brachial plexus block was performed using a peripheral nerve stimulator to locate the median nerve. All patients were administered 1.5% lidocaine 450 mg and epinephrine 5 microg mL-1. Patients were allocated randomly to one of two groups. Neostigmine 500 microg was added in group N, and saline 1 mL in group S.ResultsThe duration of analgesia did not significantly differ between groups [mean (SD)]: 812.5 (456.9) for group S vs. 746.7 (474.1) min for group N (P > 0.05). The need for supplementary analgesia did not significantly differ between groups: 4.4 (1.5) extra doses for group S vs. 3.8 (2.2) extra doses for group N (P > 0.05). Visual analogue pain scores and occurrence of side-effects did not significantly differ between groups.ConclusionNeostigmine does not seem to be of clinical value for peripheral nerve blocks.

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