• A Sánchez-Miralles, G Castellanos, R Badenes, and R Conejero.
• Servicio de Medicina Intensiva, Hospital Universitario San Juan de Alicante, Alicante, España.
• Med Intensiva. 2013 Mar 1;37(2):99-109.

AbstractSeriously ill patients frequently present intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) as complications, and the associated mortality is very high. This review offers an update on the most controversial aspects of these entities: factors favoring their appearance, the most common causes, prognosis, and methods of measuring intra-abdominal pressure (IAP), physiopathological consequences in relation to the different organs and systems, and the currently accepted treatment measures (medical and/or surgical). Simultaneously to the strictly physical mechanisms of injury, such as direct compression of intra-abdominal organs and vessels, the transmission of IAP to other compartments, and the drop in cardiac output, a series of immune-inflammatory mediators generated in the intestine itself may also intervene. Hypoperfusion, sustained ischemia and the ischemia-reperfusion phenomenon, would act upon the microbiota, intestinal epithelium and intestinal immune system, triggering a systemic inflammatory response and multiorgan dysfunction that appears in the final stages of ACS.Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.

11 keywords...

hide…