• B S Galer, S Bruehl, and R N Harden.
• Department of Neurology and Anesthesiology, Multidisciplinary Pain Center, University of Washington School of Medicine, Seattle 98105, USA.
• Clin J Pain. 1998 Mar 1;14(1):48-54.

ObjectiveTo assess the ability of the International Association for the Study of Pain Complex Regional Pain Syndrome (CRPS) diagnostic criteria and associated features to discriminate between CRPS patients and patients with painful diabetic neuropathy.DesignProspective assessment of signs and symptoms in a series of CRPS and diabetic neuropathy patients.SettingUniversity of Washington Multidisciplinary Pain Center.PatientsA consecutive series of 18 CRPS patients and 30 diabetic neuropathy patients.InterventionsPatients completed a 10-item patient history questionnaire assessing symptoms of CRPS prior to medical evaluation. The evaluating physician completed a 10-item patient examination questionnaire assessing objective signs of CRPS.Outcome MeasuresThe analyses conducted were designed to test the ability of CRPS signs and symptoms and associated features to discriminate between CRPS patients and diabetic neuropathy patients.ResultsData analysis suggested that CRPS decision rules may lead to overdiagnosis of the disorder. Diagnosis based on self-reported symptoms can be diagnostically useful in some circumstances. The addition of trophic tissue changes, range of motion changes, and "burning" quality of pain did not improve diagnostic accuracy, but the addition of motor neglect signs did. Test of a CRPS scoring system resulted in improved accuracy relative to current criteria and decision rules.ConclusionsPoorly understood disorders lacking prototypical signs/symptoms and diagnostic laboratory testing must rely on the development of reliable diagnostic guidelines. The results of this study should assist in the further refinement of the CRPS diagnostic criteria.

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