• Chung-Eun Ha, Nadhipuram V Bhagavan, Miki Loscalzo, Stephen K Chan, Huy V Nguyen, Carlos N Rios, and Stacey A A Honda.
• Department of Native Hawaiian Health, John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, HI (CH).
• Hawaii J Med Public Health. 2014 Jun 1;73(6):172-4.

AbstractThis article describes an interesting case of a patient presenting with congestive heart failure found to have restrictive cardiomyopathy with initial laboratory evaluation showing hypogammaglobuminemia without a monoclonal band on serum and urine electrophoresis. This case highlights the clinically significant cardiac manifestation caused by protein misfolding, a defect in protein homeostasis. In addition, the utility of a relatively newer laboratory test, serum free light chains as well as the importance of clinical and pathophysiologic correlation is also discussed. We present a relatively uncommon cause of heart disease, cardiac amyloidosis in a patient with a systemic plasma cell dyscrasia, and multiple myeloma.

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