• P Vera, L Zapata, I Gich, J Mancebo, and A J Betbesé.
• Unidad de Medicina Intensiva, Hospital de la Santa Creu i Sant Pau, Barcelona, España. pvera@santpau.cat
• Med Intensiva. 2012 Dec 1;36(9):619-25.

BackgroundThe objective was to study the antipyretic and hemodynamic effects of three different drugs used to treat fever in critically ill patients.MethodsDesign And SettingProspective, observational study in a 16-bed, general ICU of a university hospital.Patient PopulationWe studied 150 patients who had a febrile episode (temperature>38°C): 50 received paracetamol, 50 metamizol and 50 dexketoprofen.InterventionsNone. Body temperature, systolic, diastolic and mean arterial pressure, heart rate, central venous pressure and oxygen saturation were determined at baseline and at 30, 60 and 120minutes after infusion of the drug. Additionally, we recorded temperature 180minutes after starting drug infusion. Diuresis and the need for or change of dose of vasodilator or vasoconstrictor drugs were also recorded.ResultsPatient characteristics, baseline temperature and hemodynamics were similar in all groups. We observed a significant decrease of at least 1°C in temperature after 180minutes in 38 patients treated with dexketoprofen (76%), in 36 with metamizol (72%), and in 20 with paracetamol (40%) (p<0.001). After 120minutes, the mean decrease in mean arterial pressure was 8.5±13.6mmHg with paracetamol, 14.9±11.8mmHg with metamizol, and 16.8±13.7mmHg with dexketoprofen (p=0.005).ConclusionsDexketoprofen was the most effective antipyretic agent at the doses tested. Although all three drugs reduced mean arterial pressure, the reduction with paracetamol was less pronounced.Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.

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