• Medicina intensiva · Apr 2013

    Review

    [Dosage of antipseudomonal antibiotics in patients with acute kidney injury subjected to continuous renal replacement therapies].

    • E Carcelero San Martín and D Soy Muner.
    • Servicio de Farmacia, Hospital Clínic Barcelona, Barcelona, España. ecarcele@clinic.ub.es
    • Med Intensiva. 2013 Apr 1;37(3):185-200.

    AbstractCritically ill patients are often affected by infections produced by Pseudomonas, which can be a cause of sepsis and renal failure. Early and adequate antibiotic treatment at correct dosage levels is crucial. Acute kidney injury is also frequent in critically ill patients. In those patients who require renal replacement therapy, continuous techniques are gaining relevance as filtering alternatives to intermittent hemodialysis. It must be taken into account that many antibiotics are largely cleared by continuous renal replacement therapies (CRRT). The aim of this review is to assess the clinical evidence on the pharmacokinetics and dosage recommendations of the main antibiotic groups used to treat Pseudomonas spp. infections in critically ill patients subjected to CRRT.Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.

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