• Thrombosis research · May 2014

    Review

    Developing individualized coagulation profiling of disease risk: thrombin generation dynamic models of the pro and anticoagulant balance.

    • Kathleen E Brummel-Ziedins.
    • University of Vermont, Department of Biochemistry, 208 South Park Drive, Colchester, Vermont 05446. Electronic address: Kathleen.brummel@uvm.edu.
    • Thromb. Res. 2014 May 1;133 Suppl 1:S9-S11.

    AbstractGlobal assays and computational models have advanced research into the realm of individualized profiling of hemostatic states. This brief review will describe one computational approach which utilizes an integrated method that evaluates the dynamics of thrombin generation by defining interactions of the pro and anticoagulant proteins, enzymes and cofactors based upon individualized concentrations of select factors. This plasma composition based computational modeling can provide a mechanism based bridge between empirical global assays of coagulation and individualized risk prediction.Copyright © 2014. Published by Elsevier Ltd.

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