• Semin Respir Crit Care Med · Apr 2008

    Review

    Pulmonary histoplasmosis.

    • Chadi A Hage, L Joseph Wheat, James Loyd, Stephen D Allen, Deborah Blue, and Kenneth S Knox.
    • Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
    • Semin Respir Crit Care Med. 2008 Apr 1;29(2):151-65.

    AbstractPulmonary manifestations of histoplasmosis were last reviewed in Seminars in 2004. This review highlights the management of the most common clinical syndromes, emphasizing recognition, diagnosis, and treatment. The reader is referred to the earlier review for subjects not fully addressed herein. Knowledge of the utility of serological testing is essential, particularly when antigen tests and cultures are negative. Antigen testing is most useful in patients with more diffuse pulmonary involvement and those with progressive disseminated disease due to the high fungal burden. Detection of antigen in bronchoalveolar lavage fluid may be particularly helpful in certain circumstances. Guidelines for antifungal therapy have been updated and will be discussed for pulmonary syndromes.

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