• Allan Jones and Robert Zachariae.
• Department of Psychology, University of Aarhus, Nobelparken, Jens Chr. Skous Vej 4, 8000 Aarhus C, Denmark. allanj@psy.au.dk
• Br J Health Psychol. 2004 Sep 1;9(Pt 3):405-18.

ObjectivesThere is growing evidence to suggest that certain psychological modulators of pain sensitivity are dependent on gender. The aim of the present study was to examine further whether cognitive-affective factors (with specific focus on situational anxiety) shown to modulate pain report and behaviour have differential effects on men's and women's response to experimentally induced pain.MethodA sample of 80 healthy university students (40 women, 40 men) was assessed on subjective measures of anxiety (situational and dispositional), anxiety-sensitivity and attitudes toward the experimental pain procedure prior to being exposed to a cold pressor test (constant temperature + 1 degrees C; +/- 1 degrees C, cut-off limit 240 s).ResultsThe present study produced three main findings: (1) No effect of gender was found on any of the pain measures; however, an interactive effect of anxiety and gender was found on measures of pain tolerance with low anxiety men displaying significantly higher pain tolerance than both low and high anxiety women. (2) Men classified as low-anxious tolerated cold pressor pain significantly longer than men classified as high-anxious, while no such effect of anxiety on pain response was observed in women. (3) Gender-specific associations were observed between other psychological variables (including anxiety-sensitivity and attitudes toward pain) and thermal pain response.ConclusionResults from the present study suggest that there are important differences in the way cognitive-affective factors impact on the pain response of men and women. Further research is needed to explore potential psychosocial and physiological mechanisms that may underlie such differences.

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