• L W Doyle and Victorian Infant Collaborative Study Group.
• The Royal Women's Hospital, Melbourne, Australia. lwd@unimelb.edu.au
• Early Hum. Dev. 2004 Nov 1;80(2):103-13.

BackgroundVery preterm infants at the borderline of viability, especially those <25 weeks of gestational age, have survived in increasing numbers in recent years, but concerns persist about their long-term outcome and their consumption of scarce hospital resources.AimsTo determine incremental changes in long-term outcome and consumption of resources by very preterm infants in the 1990s.DesignCohort study.PatientsConsecutive livebirths with gestational ages 23-27 weeks born in the state of Victoria in two discrete eras, 1991-1992 (n=401) and 1997 (n=208), and randomly selected contemporaneous normal birthweight (NBW, birthweight >2499 g) controls (1991-1992 n=265, 1997 n=198).Main Outcome MeasuresSurvival, and neurosensory impairments, disabilities and utilities, and consumption of hospital resources to 2 years of age.ResultsCompared with 1991-1992, in 1997 more infants were offered intensive care and the survival rate was higher at each week of gestation, and overall (absolute increase in survival 16%; 95% confidence interval, 8%, 24%). The largest increases in the survival and quality-adjusted survival rates were in infants at 23 weeks (31% and 20%, respectively). The incremental resource costs of improving survival and quality-adjusted survival were similar in infants of 23-24 weeks compared with those of 25-27 weeks (e.g., 112 vs. 105 days of assisted ventilation per additional survivor, or 167 vs. 180 days of assisted ventilation per additional quality-adjusted survivor, respectively).ConclusionsIncreased intensive care in the late 1990s for infants at the borderline of viability was associated with improved outcomes, at incremental costs that were not excessive compared with slightly more mature infants.

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