• Ann. Intern. Med. · Aug 1997

    Randomized Controlled Trial Multicenter Study Clinical Trial

    Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections. A randomized, double-blind trial. The Texas Medical Center Catheter Study Group.

    • I Raad, R Darouiche, J Dupuis, D Abi-Said, A Gabrielli, R Hachem, M Wall, R Harris, J Jones, A Buzaid, C Robertson, S Shenaq, P Curling, T Burke, and C Ericsson.
    • University of Texas M.D. Anderson Cancer Center, Houston, USA.
    • Ann. Intern. Med. 1997 Aug 15;127(4):267-74.

    BackgroundCentral venous catheters are a principal source of nosocomial bloodstream infections, which are difficult to control.ObjectiveTo determine the efficacy of catheters coated with minocycline and rifampin in preventing catheter-related colonization and bloodstream infections.DesignMulticenter, randomized clinical trial.SettingFive university-based medical centers.Patients281 hospitalized patients who required 298 triple-lumen, polyurethane venous catheters.Intervention147 catheters were pretreated with tridodecylmethyl-ammonium chloride and coated with minocycline and rifampin. Untreated, uncoated catheters (n = 151) were used as controls.MeasurementsQuantitative catheter cultures, blood cultures, and molecular typing of organisms to determine catheter-related colonization and bloodstream infections.ResultsThe group with coated catheters and the group with uncoated catheters were similar with respect to age, sex, underlying diseases, degree of immunosuppression, therapeutic interventions, and risk factors for catheter infections. Colonization occurred in 36 (26%) uncoated catheters and 11 (8%) coated catheters (P < 0.001). Catheter-related bloodstream infection developed in 7 patients (5%) with uncoated catheters and no patients with coated catheters (P < 0.01). Multivariate logistic regression analysis showed that coating catheters with minocycline and rifampin was an independent protective factor against catheter-related colonization (P < 0.05). No adverse effects related to the coated catheters or antimicrobial resistance were seen. An estimate showed that the use of coated catheters could save costs.ConclusionsCentral venous catheters coated with minocycline and rifampin can significantly reduce the risk for catheter-related colonization and bloodstream infections. The use of these catheters may save costs.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…