• E Frutos Bernal, F J Rubio Gil, J C Martín Corral, L A Marcos Prieto, and J González Robledo.
• Departamento Estadística, Universidad de Salamanca, Salamanca, España. efb@usal.es
• Med Intensiva. 2013 Jun 1; 37 (5): 327-32.

ObjectiveTo describe the factors associated to mortality of patients with severe traumatic brain injury (TBI).DesignA retrospective observational study was made of patients with severe TBI covering the period between 1 January 2007 and 31 December 2010.SettingVirgen de la Vega Hospital, Salamanca (Spain).PatientsAll patients hospitalized during the consecutive study period.Main Variables Of InterestThe dependent variable has been the death rate, while the independent variables were divided into two groups: epidemiological and clinical.ResultsThe mean patient age was the 50.84 years; 75.5% were males. The average score on the Glasgow Coma Scale (GCS) was 5.09, and the average Injury Severity Score (ISS) was 30.8. Higher mortality was observed in older patients with a higher ISS score. A total of 68.1% of the patients in which intracranial pressure (ICP) was monitored showed intracranial hypertension (ICH). The mortality rate in patients with severe TBI was 36.8%, and was associated mainly to a lower GCS score, the existence of hyperglycemia, coagulopathy, hypoxemia, the presence of mydriasis and shock. The independent mortality indicators in patients with severe TBI were the existence of mydriasis (OR: 32.75), the GCS score (OR: 2.65) and hyperglycemia (OR: 6.08).ConclusionsThe existence of mydriasis, the GCS score and hyperglycemia should be taken into account as prognostic factors in TBI patients.Copyright © 2011 Elsevier España, S.L. and SEMICYUC. All rights reserved.

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