• Eur. J. Heart Fail. · Nov 2006

    Randomized Controlled Trial

    Cardiogenic shock after primary percutaneous coronary intervention: Effects of levosimendan compared with dobutamine on haemodynamics.

    • Martín J García-González, Alberto Domínguez-Rodríguez, Julio J Ferrer-Hita, Pedro Abreu-González, and Miguel Bethencourt Muñoz.
    • Coronary Care Unit, Department of Cardiology, Hospital Universitario de Canarias, Ctra. La Cuesta-Taco. Ofra s/n. S, Cristóbal de La Laguna, E-38320 Sta. Cruz de Tenerife, Spain. mjgg181262@hotmail.com
    • Eur. J. Heart Fail. 2006 Nov 1;8(7):723-8.

    BackgroundLevosimendan is a new calcium sensitizer with positive inotropic properties. Cardiac power output (CPO) has been shown to be instrumental in the diagnosis of cardiogenic shock (CS) and is an important determinant of outcomes.AimsTo evaluate the haemodynamic effects of levosimendan compared to dobutamine in acute myocardial infarction (AMI) patients revascularised by primary percutaneous coronary intervention (PCI), who developed CS.Methods And ResultsTwenty two consecutive AMI patients revascularised by PCI, who developed CS, were randomly assigned to levosimendan (24 microg kg(-1) bolus plus 24-h continuous infusion 0,1 microg kg(-1) min(-1)) or dobutamine (initial dose 5 microg kg(-1) min(-1), with a maximum dose adjustment in order to reach the desired haemodynamic effect). Evaluations were performed from baseline to 30 h. The primary end-point was an increase > or =30% in CPO, after 24 h of therapy. The baseline clinical and haemodynamic characteristics were similar in both groups. Levosimendan had a consistently better effect on CPO than dobutamine, while the decrease in PCWP was similar.ConclusionThe primary objective of our study was achieved better by the end of the 24 h infusion of levosimendan than by dobutamine.

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