• M C Papanna, N Al-Hadithy, B V Somanchi, M D Sewell, P M Robinson, S A Khan, and R A Wilkes.
• Dept of Orthopaedics and Limb Reconstruction, Salford Royal Hospital, Salford, UK; Doncaster Royal Infirmary, Doncaster DN2 5LT, UK. drmadhavan@hotmail.com
• Injury. 2012 Jul 1; 43 (7): 1135-40.

AbstractThe aim of the present study was to investigate the safety and efficacy of local implantation of BMP-7 for the treatment of resistant non-unions in the upper and lower limb. Fifty-two patients (30 males, mean age 52.8 years; range 20-81) were treated with local BMP-7 implantation in a bovine bone-derived collagen paste with or without revision of fixation. Thirty-six patients had closed injuries, ten had open injuries and six had infected non-unions. Patients had undergone a mean of 2 (1-5) operations prior to implantation of BMP-7. Clinical and radiological union was achieved in 94% at a mean time of 5.6 months (3-19). Two patients with subtrochanteric femoral fractures failed to achieve union secondary to inadequate fracture stabilisation, persistent unfavourable biological environment and systemic co-morbidities. One patient developed synostosis attributed to the BMP-7 application. This study demonstrates BMP-7 implanted in a bovine-derived collagen paste is an effective adjunctive treatment for resistant non-unions in the upper and lower limb.Copyright © 2012 Elsevier Ltd. All rights reserved.

32 keywords...

hide…