• Giovanni Landoni, Alberto Zangrillo, Oliviero Fochi, Giulia Maj, Anna Mara Scandroglio, Andrea Morelli, Luigi Tritapepe, Matteo Montorfano, and Antonio Colombo.
• Department of Cardiothoracic Anesthesia and Intensive Care, Università Vita-Salute San Raffaele e Istituto Scientifico San Raffaele, Milan, Italy. landoni.giovanni@hsr.it
• J. Cardiothorac. Vasc. Anesth. 2008 Aug 1;22(4):543-7.

ObjectiveMyocardial ischemic damage is reduced by volatile anesthetics in patients undergoing coronary artery bypass graft surgery. The authors tested the hypothesis that low-dose sevoflurane could decrease perioperative myocardial damage, as measured by cTnI release, when compared with placebo, in patients undergoing interventional cardiology procedures.DesignA single-blind, randomized controlled trial.SettingA university hospital.ParticipantsThirty patients undergoing stenting procedures (May 2005) were included in the present study.InterventionsThe authors randomly assigned 16 patients to breathe sevoflurane (expired end-tidal concentration 1%) and 14 patients to breathe a placebo oxygen/air mix before stenting procedures.Measurements And Main ResultsPostprocedural cardiac troponin I release was measured as a marker of myocardial necrosis. Sixteen patients had detectable cardiac troponin I levels after stenting procedures, with no difference between groups: 10 in the sevoflurane group (16 patients) versus 6 in the placebo group (14 patients) (p = 0.3). No difference in the amount of postprocedural median (interquartile range) cardiac troponin I release was noted between the sevoflurane group, 0.15 (0-4.73) ng/mL, and the placebo group, 0.14 (0-0.87) ng/mL (p = 0.4).ConclusionsMyocardial damage measured by cardiac troponin release was not reduced by the volatile anesthetic sevoflurane during interventional cardiology procedures in this study.

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