• Neuroscience letters · Feb 2011

    Involvement of dorsal hippocampal α1-adrenergic receptors in the effect of WIN55,212-2 on memory retrieval in inhibitory avoidance task.

    • Azam Moshfegh, Parvin Babaei, Shahrbano Oryan, Bahram Soltani, and Mohammad-Reza Zarrindast.
    • Department of Biology, Sciences and Research Branch, Islamic Azad University, Tehran, Iran.
    • Neurosci. Lett. 2011 Feb 4;489(2):69-73.

    AbstractIn the present study, the possible role of α1-adrenergic receptors of the dorsal hippocampus on WIN55,212-2-induced amnesia in male Wistar rats has been evaluated. As a model of learning, a step-down passive avoidance task was used. Results indicated that post-training or pre-test intra-CA1 administration of WIN55,212-2 (0.25 and 0.5 μg/rat) reduced the step-down latency, showing an amnestic response. Amnesia produced by post-training WIN55,212-2 (0.5 μg/rat) was reversed by pre-test administration of the same drug dose. Interestingly, pre-test intra-CA1 administration of α1-noradrenergic agonists, phenylephrine alone or with an ineffective dose of WIN55,212-2 (0.25 μg/rat) reversed post-training WIN55,212-2 (0.5 μg/rat)-induced retrieval impairment. On the other hand, pre-test intra-CA1 microinjection of an α1-adrenergic antagonist, prazosin (0.5 μg/rat), 2 min before administration of WIN55,212-2 (0.5 μg/rat) inhibited the pre-test WIN55,212-2 response. It may be concluded that α1-adrenergic receptors of the dorsal hippocampal CA1 regions play an important role in WIN55,212-2-induced amnesia and restoration of memory by pre-test WIN55,212-2 administration.Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…