• J Drugs Dermatol · Sep 2008

    Case Reports

    Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.

    • Julia S Lehman and Gabriel F Sciallis.
    • Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
    • J Drugs Dermatol. 2008 Sep 1;7(9):887-9.

    AbstractIdiopathic proctodynia, an enigmatic pain syndrome affecting the perianal region, can be persistent, relatively refractory to treatment, and associated with considerable psychological distress. The authors present the case of a patient with a long history of severe proctodynia that had been resistant to a range of topical and systemic treatments. With the use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% cream, the patient's pain resolved rapidly, leading to a substantially improved quality of life.

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