• Min-min Ma, Qin Yin, Ge-lin Xu, Ren-liang Zhang, Shuang-gen Zhu, Xin-ying Fan, Wu-sheng Zhu, and Xin-feng Liu.
• Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, China.
• Zhonghua Yi Xue Za Zhi. 2011 May 24;91(19):1303-7.

ObjectiveTo analyze the predictors of Wingspan in-stent restenosis (ISR) for the treatment of symptomatic intracranial arterial stenosis.MethodsBetween January 2007 and November 2009, 42 patients with symptomatic intracranial arterial stenosis registered in Nanjing stroke registry program (NSRP) were treated with Wingspan stent system. Clinical and follow-up results were retrospectively analyzed. They were divided into the non-restenosis and restenosis groups according to their follow-up imaging data. ISR was defined as > 50% stenosis within 5 mm or adjacent to stent or an absolute luminal loss > 20%. The analysis of stepwise multivariate Cox regression was performed to evaluate the independent predictive factors.ResultsISR was found in 15 patients (15/42, 35.7%) with 16 lesions (16/43, 37.2%) at a median follow-up period of 7 months (range: 4 - 23). Diabetes (HR = 0.281; 95%CI = 0.088 - 0.898; P = 0.032) and stent diameter (HR = 0.213; 95%CI = 0.049 - 0.918; P = 0.038) were two independent predictors for ISR.ConclusionDiabetes and stent diameter may be two independent predictors for ISR after a treatment of Wingspan system.

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