• C Marti-Macia, T M Tomasa, A Sancho, A Galán, J Fernández-Llamazares, V Macias, J Roca, R Gonzalez-Celador, É Amestoy, J Klamburg, and investigadores del estudio COFRADE.
• Servicio de Medicina Intensiva, Bioquímica, Cirugía y Epidemiología, Hospital Universitari Germans Trias i Pujol, Badalona, España. Electronic address: claramarti@yahoo.com.
• Med Intensiva. 2014 Apr 1;38(3):146-53.

ObjectiveTo determine if NGAL value exceeding 150 ng/mL is a good diagnostic test for acute renal failure in critically ill patients.DesignProspective, observational cohort.SettingIntensive Care Unit and Cardiac Surgery Intensive Care Service at Hospital Germans Trias I Pujol.ParticipantsPatients admitted to the Intensive Care department the Designated days in the studio.InterventionsAnalysis of serum creatinine blood given from 7 days prior to the start of the study, and daily during 4 weeks and by determination of NGAL urine test in frozen sample, analyzer ARCHITECT (Abbott Diagnostics) determined by immunoassay the day baseline and 2 times a week for 4 weeks, analysis of the stay and mortality.ResultsA total of 529 NGAL samples were obtained from 46 patients. 37% of patients had a value of NGAL>150 ng/mL. The Sensivity of the test to diagnose acute renal failure was 69%, Specifity was 75,7%. However, the Positive Predictive Test Value was 53%, which means that 47% of patients with high NGAL did not develop AKI. A NGAL >150 mg/dL was associated with a significantly higher SOFA and a longer stay in the ICU. The mortality of patients with elevated NGAL was 58.8%.ConclusionsA NGAL>150 ng/mL does not seem to be an excellent test for AKI in critically ill patients but is associated with a worse prognosis.Copyright © 2012 Elsevier España, S.L. y SEMICYUC. All rights reserved.

41 keywords...

hide…