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Hum Vaccin Immunother · Jan 2014
ReviewThe evolution of the EGFRvIII (rindopepimut) immunotherapy for glioblastoma multiforme patients.
- Michelle Paff, Daniela Alexandru-Abrams, Frank P K Hsu, and Daniela A Bota.
- a Department of Neurological Surgery ; University of California, Irvine ; Orange , CA USA.
- Hum Vaccin Immunother. 2014 Jan 1;10(11):3322-31.
AbstractGlioblastoma Multiforme (GBM) is the most common type of brain tumor and it is uniformly fatal. The community standard of treatment for this disease is gross or subtotal resection of the tumor, followed by radiation and temozolomide. At recurrence bevacizumab can be added for increased progression free survival. Many challenges are encountered while trying to devise new drugs to treat GBM, such as the presence of the blood brain barrier which is impermeable to most drugs. Therefore in the past few years attention was turned to immunological means for the treatment of this devastating disease. EGFRvIII targeting has proven a good way to attack glioblastoma cells by using the immune system. Although in still in development, this approach holds the promise as a great first step toward immune-tailored drugs for the treatment of brain cancers.
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