• M Ruiz-Bailén, F J Romero-Bermejo, M Expósito-Ruiz, F Zamora-Zamora, M J Martínez-Ramírez, A M Castillo-Rivera, J A Ramos-Cuadra, M Ramírez-Sánchez, R Vázquez-García, and Grupo ARIM.
• Unidad de Gestión Clínica de Cuidados Críticos y Urgencias, Hospital Médico-Quirúrgico del Complejo Hospitalario de Jaén, Jaén, España. Electronic address: ruizbailen@gmal.com.
• Med Intensiva. 2014 Jan 1;38(1):11-20.

ObjectivesTo evaluate the effects of the early administration of statins during acute myocardial infarction (MI).DesignA retrospective cohort study was carried out.SettingNational (Spain).Patients Or ParticipantsPatients included in the ARIAM registry from January 1999 to December 2008 with a diagnosis of MI.InterventionsNone.Main VariablesWe used logistic regression analysis and propensity scoring to determine whether the administration of statins during the first 24h of MI acts as a protective factor against: 1) mortality, 2) the incidence of lethal arrhythmias, or 3) cardiogenic shock.ResultsA total of 36 842 patients were included in the study. Statins were administered early in 50.2% of the patients. Statin administration was associated with younger patients with known previous dyslipidemia, obesity, a history of ischemic heart disease, heart failure, presence of sinus tachycardia, use of beta-blockers, angiotensin-converting enzyme inhibitors, thrombolysis and percutaneous coronary intervention. Mortality was 8.2% (13.2% without statin versus 3% with statin, P<.001). Multivariate analysis demonstrated that statin administration acted as a protective factor against mortality (adjusted OR 0.518, 95%CI 0.447 to 0.601). Continued use of statins was associated with a reduction in mortality (adjusted OR 0.597, 95%CI 0.449 to 0.798), and the start of treatment was a protective factor against mortality (adjusted OR 0.642, 95%CI 0.544 -0.757). Statin therapy also exerted a protective effect against the incidence of lethal arrhythmias and cardiogenic shock.ConclusionsThese results suggest that early treatment with statins in patients with MI is associated with reduced mortality.Copyright © 2012 Elsevier España, S.L. and SEMICYUC. All rights reserved.

16 keywords...

hide…