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Support Care Cancer · Jan 2009
ReviewThe cognitive effects of opioids in cancer: a systematic review.
- Geana Paula Kurita, Lena Lundorff, Cibele Andrucioli de Mattos Pimenta, and Per Sjøgren.
- Multidisciplinary Pain Centre, Dept. 7612, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark. geana@rh.regionh.dk
- Support Care Cancer. 2009 Jan 1;17(1):11-21.
Objective And MethodsIn order to better understand the effects of opioids on the cognitive function in cancer pain patients, a literature search was performed in PubMed, EMBASE, PsycInfo, CINAHL and Lilacs databases. Ten controlled trials were selected and classified according to the study design, the level of evidence, and opioid regimen.ResultSix studies reported association between poor cognitive performance (reaction time, attention, balance, and memory) and opioid use.ConclusionThese cognitive deficits were captured with neuropsychological tests; however, their clinical relevance is still uncertain.
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