• Paediatric anaesthesia · Jul 2007

    Ketamine disposition in children presenting for procedural sedation and analgesia in a children's emergency department.

    • David Herd and Brian J Anderson.
    • Department of Paediatrics, Starship Children's Hospital, Auckland, New Zealand. david.herd@mac.com
    • Paediatr Anaesth. 2007 Jul 1;17(7):622-9.

    BackgroundThe aim of this study was to describe ketamine pharmacokinetics in children to simulate time-concentration profiles to predict duration of concentrations associated with anesthesia, arousal and analgesia.MethodsChildren presenting for painful procedures in the Emergency Dept were given ketamine 1-1.5 mgxkg(-1) i.v. Blood was assayed for ketamine on 3-6 occasions (median 3) over the subsequent 14-152 min (median 28.5). A population pharmacokinetic analysis was undertaken by using nonlinear mixed effects models (NONMEM). Simulation was used to predict time-concentration profiles in this cohortResultsThere were 188 observations from 54 children (age 8.3 sd 3.5 years, weight 32.5 sd 15.6 kg). A two-compartment (central, peripheral) linear disposition model fitted data better than a one-compartment model. Population parameter estimates and their between subject variability (BSV), standardized to a 70-kg person using allometric models, were central volume (V1) 38.7 (BSV 64%) l.70 kg(-1), peripheral volume of distribution (V2) 102 (51.7%) l.70 kg(-1), clearance (CL) 90 (38.1%) l.h(-1) 70 kg(-1) and intercompartment clearance (Q) 215 (19%) l.h(-1) 70 kg(-1). At 10 min half of the children given 1 mgxkg(-1) will have a serum concentration below 0.75 mgxl(-1). This is a concentration associated with 'awakening' in adults. However, almost all the children will still have a serum concentration above 0.1 mgxl(-1), a level associated with analgesia in adults.ConclusionsKetamine 1 mgxkg(-1) i.v. provides satisfactory serum concentrations for children undergoing sedation for painful procedures of <5-min duration and produces concentrations associated with analgesic effect for more than 10 min. Clearance increases with decreasing age in children. The relationship between serum concentration and effect is poorly defined in children.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…