• Vaccine · Feb 2016

    Randomized Controlled Trial Multicenter Study

    Long-term immunogenicity and safety of an investigational herpes zoster subunit vaccine in older adults.

    • Roman Chlibek, Karlis Pauksens, Lars Rombo, Gini van Rijckevorsel, Jan H Richardus, Georg Plassmann, Tino F Schwarz, Grégory Catteau, Himal Lal, and Thomas C Heineman.
    • Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
    • Vaccine. 2016 Feb 3; 34 (6): 863-8.

    BackgroundAn investigational subunit vaccine containing the varicella-zoster virus (VZV) glycoprotein E (gE) and the AS01B adjuvant system is being evaluated for the prevention of herpes zoster (HZ) in older adults. A phase II trial evaluating different formulations of this vaccine (containing 25μg, 50μg, or 100μg gE) was conducted in adults ≥60 years of age and showed that all formulations elicited robust cellular and humoral immune responses for up to 3 years after vaccination. In this follow-up study in subjects who received two doses of the 50μg gE/AS01B formulation (HZ/su), we assessed the persistence of the immune responses for up to 6 years after vaccination.MethodsThis phase II, open-label, multicenter, single-group trial conducted in the Czech Republic, Germany, Sweden, and the Netherlands followed 129 subjects who had received two doses (2 months apart) of HZ/su during the initial trial. Vaccine-induced immune responses (frequencies of gE-specific CD4(+) T cells expressing ≥2 activation markers and serum anti-gE antibody concentrations) were evaluated at 48, 60, and 72 months after the first HZ/su dose.ResultsSix years after vaccination with HZ/su, gE-specific cell-mediated immune responses and anti-gE antibody concentrations had decreased by 20-25% from month 36, but remained higher than the prevaccination values. At month 72, the gE-specific cell-mediated immune response was 3.8 times higher than the prevaccination value (477.3 vs. 119.4 activated gE-specific CD4(+) T cells per 10(6) cells), and the anti-gE antibody concentration was 7.3 times higher than the prevaccination value (8159.0 vs. 1121.3mIU/mL). No vaccine-related serious adverse events were reported between months 36 and 72.ConclusionsgE-specific cellular and humoral immune responses persisted for 6 years after two-dose vaccination with HZ/su in healthy older adults. No safety concerns were identified.Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

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