• Elias A Giraldo, Jennifer E Fugate, Alejandro A Rabinstein, Giuseppe Lanzino, and Eelco F M Wijdicks.
• Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. giraldo.elias@mayo.edu
• Neurocrit Care. 2011 Jun 1;14(3):427-32.

BackgroundCerebral vasospasm has become the most concerning complication in patients with aneurysmal subarachnoid hemorrhage (aSAH) seen in the neurosciences intensive care unit (NSICU). Hemodynamic augmentation is frequently used to treat cerebral ischemia from vasospasm. In the last 5 years, posterior reversible encephalopathy syndrome (PRES) has been reported in three single case reports as a complication of hemodynamic augmentation. We describe an additional three patients seen in our institution.MethodsDescription of clinical course of three patients with a secured aneurysm treated with hemodynamic augmentation for cerebral vasospasm.ResultsWe identified three patients (two female and one male), ranged in age from 62 to 70 years who developed PRES after treatment with induced or permissive arterial hypertension. During their NSICU stay, case 1 had worsening headache and confusion, case 2 and 3 had a decline in level of consciousness. Neuroimaging was compatible with vasogenic edema characteristic of PRES. Arterial blood pressure was reduced with a complete clinical and imaging resolution of PRES.ConclusionsPRES can be a cause of deterioration in patients with aSAH treated with hemodynamic augmentation. PRES should be differentiated from evolving infarctions due to cerebral vasospasm. Clinical manifestations and neuroimaging findings are reversible after gradual normalization of blood pressure.

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