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Antimicrob. Agents Chemother. · Apr 2005
Comparative StudyComparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease.
- Milagros Corrales, Rubén Cardozo, María Asunción Segura, Julio A Urbina, and Miguel Angel Basombrío.
- Laboratorio de Patología Experimental, Facultad de Ciencias de la Salud, Universidad Nacional de Salta, Buenos Aires, Salta, Argentina.
- Antimicrob. Agents Chemother. 2005 Apr 1;49(4):1556-60.
AbstractWe carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.
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