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Support Care Cancer · Mar 2005
Review Comparative StudyContribution to variability in response to opioids.
- Geoffrey W Hanks and Colette Reid.
- Department of Palliative Medicine, Bristol Haematology and Oncology Centre, University of Bristol, Horfield Road, Bristol, BS2 8ED, UK. debbie.ashby@bristol.ac.uk
- Support Care Cancer. 2005 Mar 1;13(3):145-52.
AbstractOpioids are the oldest and most effective agents for the short- and long-term control of severe pain, particularly chronic cancer pain palliation. However, morphine and other opioids display wide variations in pharmacological efficacy and tolerability, and a significant number of patients are unable to achieve adequately controlled pain at doses that do not produce intolerable adverse effects. This article reviews factors that affect the efficacy and tolerability of opioid analgesics and clinical strategies for successful pain mangement.
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