• Eur J Pharm Sci · Dec 1999

    Review

    The biopharmaceutics classification system (BCS): class III drugs - better candidates for BA/BE waiver?

    • H H Blume and B S Schug.
    • SocraTec R&D, Feldbergstrasse 59, 61440, Oberursel, Germany. h.h.blume@t-online.de
    • Eur J Pharm Sci. 1999 Dec 1;9(2):117-21.

    AbstractCurrent guidelines (CPMP Note for Guidance in Europe and FDA Guidance for Industry in the USA) consider a waiver of bioavailability/bioequivalence studies for immediate release dosage forms of highly soluble, highly permeable drug substances (Class I according to the BCS). In this paper, a waiver of BA/BE studies is being proposed also for Class III compounds (high solubility and low permeability) in fast dissolving products without excipients which may modify gastro-intestinal transit or membrane permeation. This type of drug substance may be an even better candidate for a waiver as, in this case, bioavailability will not so much depend on the formulation characteristics, as on drug substance properties (e.g. permeability).

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