• Br J Anaesth · Oct 2000

    Lack of pre-emptive analgesic effects of local anaesthetics on neuropathic pain.

    • S Abdi, D H Lee, S K Park, and J M Chung.
    • Department of Anesthesiology and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.
    • Br J Anaesth. 2000 Oct 1;85(4):620-3.

    AbstractWe investigated the significance of pre-emptive analgesia using a well-known model of neuropathic pain in rats. Lignocaine, bupivacaine or saline was applied locally to the left L5-L6 spinal nerve before or 4 days after nerve injury. Mechanical allodynia was then evaluated before and after injury. Pre- and post-injury treatment with local anaesthetics both resulted in a two- to threefold increase in the pain threshold, as manifested by a significant increase in von Frey measurements. However, this effect lasted only 24 h. Our study in rats questions the beneficial effect of a single dose of local anaesthetic as pre-emptive analgesia.

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