• Alexandre Tellechea Rotta, Cláudia Laura Barberio Kunrath, and Budi Wiryawan.
• State University of New York at Buffallo, NY 14222, USA. arotta@buffalo.edu
• J Pediatr (Rio J). 2003 Nov 1;79 Suppl 2:S149-60.

ObjectiveTo review the current support and treatment strategies of the acute respiratory distress syndrome.Data SourcesOriginal data from our research laboratory and from representative scientific articles on acute respiratory distress syndrome and acute lung Injury searched through Medline.Summary Of The FindingsDespite advances in the understanding of the pathogenesis of acute respiratory distress syndrome, this syndrome still results in significant morbidity and mortality. Mechanical ventilation, the main therapeutic modality for acute respiratory distress syndrome, is no longer considered simply a support modality, but a therapy capable of influencing the course of the disease. New ventilation strategies, such as high-frequency oscillatory ventilation appear to be promising. This text reviews the current knowledge of acute respiratory distress syndrome management, including conventional and non-conventional ventilation, the use of surfactant, nitric oxide, modulators of inflammation, extracorporeal membrane oxygenation and prone position.ConclusionsThe last decade was marked by significant advances, such as the concept of protective ventilation for acute respiratory distress syndrome. The benefit of alternative strategies, such as high-frequency oscillatory ventilation, the use of surfactant and immunomodulators continue to be the target of study.

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