• Curr Opin Anaesthesiol · Apr 2009

    Review

    The role of recombinant-activated factor VII in bleeding trauma patients.

    • Richard P Dutton and Bianca M Conti.
    • Department of Anesthesiology, University of Maryland School of Medicine, Division of Anesthesiology, R. Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, Maryland 21201, USA.
    • Curr Opin Anaesthesiol. 2009 Apr 1;22(2):299-304.

    Purpose Of ReviewExsanguinating hemorrhage and postshock organ failure account for 35-40% of deaths from trauma, and there is an increasing recognition of the importance of coagulopathy in the evolution of this disease.Recent FindingsSince 1999, case reports, small series, retrospective studies and a few controlled trials have reported the use of recombinant-activated factor VII (rFVIIa) as an adjunct for reversal of coagulopathy in trauma patients, and numerous other publications have examined the use of rFVIIa in related conditions such as traumatic brain injury, hemorrhagic stroke and uncontrolled surgical bleeding.SummaryWe present a brief discussion of the mechanism of action of rFVIIa and its role in facilitating hemostasis and a review of the recent medical literature on the use of rFVIIa in trauma patients, including current guidelines and controversies.

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