• J Arthroplasty · Aug 2014

    Liposomal bupivacaine versus traditional periarticular injection for pain control after total knee arthroplasty.

    • Deren T Bagsby, Phillip H Ireland, and R Michael Meneghini.
    • Department of Orthopaedic Surgery, Indiana University Health Physicians, Indiana University School of Medicine, Indianapolis, Indiana.
    • J Arthroplasty. 2014 Aug 1;29(8):1687-90.

    AbstractThe purpose of this study was to compare a novel liposomal bupivacaine to traditional peri-articular injection (PAI) in a multi-modal pain protocol for total knee arthroplasty (TKA). A retrospective cohort study compared 85 consecutive patients undergoing TKA with a traditional PAI of ropivacaine, epinephrine and morphine to 65 patients with a liposomal bupivacaine PAI. After the initial 24h, inpatient self-reported pain scores were higher in the liposomal bupivacaine group compared to the traditional PAI group (P = 0.04) and a smaller percentage (16.9%) of patients in the liposomal bupivacaine group rated their pain as "mild" compared to the traditional group (47.6%). Liposomal bupivacaine PAI provided inferior pain control compared to the less expensive traditional PAI in a multi-modal pain control program in patients undergoing TKA.Copyright © 2014 Elsevier Inc. All rights reserved.

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