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- E Mortier, M Struys, T De Smet, L Versichelen, and G Rolly.
- Department of Anaesthetics, University Hospital Gent, Belgium.
- Anaesthesia. 1998 Aug 1;53(8):749-54.
AbstractTen patients, undergoing elective orthopaedic surgery under spinal anaesthesia, were sedated with propofol using a closed-loop feedback control system. The bispectral index (BIS), a new processed EEG parameter, was used as control variable. Propofol administration was controlled by a patient individualised adaptive model-based controller incorporating target-controlled infusion technology combined with a pharmacokinetic-dynamic model. This feedback control system for propofol administration proved to be adequate and safe. BIS was found to be well suited as control variable.
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