• Respiratory care · Jan 2014

    EXPERIMENTAL MODEL OF ATELECTASIS IN NEWBORN PIGLETS.

    • Talitha Comaru, Humberto Holmer Fiori, Renato Machado Fiori, Priscila Padoim, Jaqueline Basso Stivanin, and Vinicius Duval da Silva.
    • Postgraduate Program in Medicine-Pediatrics and Child Health.
    • Respir Care. 2014 Jan 1;59(1):121-6.

    BackgroundThere are few studies using animal models in chest physical therapy. However, there are no models to assess these effects in newborns. This study aimed to develop a model of obstructive atelectasis induced by artificial mucus injection in the lungs of newborn piglets, for the study of neonatal physiotherapy.MethodsThirteen newborn piglets received artificial mucus injection via the endotracheal tube. X-rays and blood gas analysis confirmed the atelectasis.ResultsThe model showed consistent results between oxygenation parameters and radiological findings. Ten (76.9%) of the 13 piglets responded to the intervention. This did not significantly differ from the expected percentage of 50% by the binomial test (95% CI 46.2-95%, P = .09).ConclusionsOur model of atelectasis in newborn piglets is both feasible and appropriate to evaluate the impact of physical therapies on atelectasis in newborns.

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