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J. Am. Soc. Nephrol. · Feb 2014
ReviewRemote ischemic preconditioning and renoprotection: from myth to a novel therapeutic option?
- Natig Gassanov, Amir M Nia, Evren Caglayan, and Fikret Er.
- Department of Internal Medicine III, University of Cologne, Cologne, Germany;
- J. Am. Soc. Nephrol. 2014 Feb 1;25(2):216-24.
AbstractThere is currently no effective prophylactic regimen available to prevent contrast-induced AKI (CI-AKI), a frequent and life-threatening complication after cardiac catheterization. Therefore, novel treatment strategies are required to decrease CI-AKI incidence and to improve clinical outcomes in these patients. Remote ischemic preconditioning (rIPC), defined as transient brief episodes of ischemia at a remote site before a subsequent prolonged ischemia/reperfusion injury of the target organ, is an adaptational response that protects against ischemic and reperfusion insult. Indeed, several studies demonstrated the tissue-protective effects of rIPC in various target organs, including the kidneys. In this regard, rIPC may offer a novel noninvasive and virtually cost-free treatment strategy for decreasing CI-AKI incidence. This review evaluates the current experimental and clinical evidence for rIPC as a potential renoprotective strategy, and discusses the underlying mechanisms and key areas for future research.
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