• Varuni Gunasekera, Edzard Ernst, and Daniel George Ezra.
• Western Eye Hospital, London, United Kingdom.
• Ophthalmology. 2008 Mar 1;115(3):435-439.e2.

ObjectiveTo identify the most popular forms of complementary and alternative medicine (CAM) for glaucoma on the Internet and to assess the quality of the most popular Web sites addressing CAM for glaucoma.DesignSystematic Internet-based search.MethodsUsing a predefined search algorithm, Web sites most likely to receive hits from people searching the Internet for information on CAM therapies for glaucoma were identified.Main Outcome MeasuresWeb sites were evaluated for quality based on the Sandvik score. Each Web site was also assessed for external validation based on listing on the Health on the Net (HON) Foundation Web site in accordance with their code of approval. Finally, the risk each Web site potentially posed to patients was assessed using a previously described scoring method.ResultsTwenty-one Web sites were included in our study. Forty-four different CAM therapies were encountered; vitamin C supplements, forskolin, and diet and lifestyle modulation were the most common CAMs discussed. The mean Sandvik score for all Web sites was 9.4 (standard deviation, 2.6). Only one Web site was listed in the HON Foundation code of approval. Two of the 21 Web sites received the highest risk scores of 3 of a potential 4 points. None of the Web sites discouraged adhering to a clinician's advice. Fourteen of the 21 Web sites assessed provided commercial details promoting CAM, with the possibility of purchasing remedies or arranging consultations. Thirteen Web sites provided opinions and experiences without factual details.ConclusionsMedical information conveyed over the Internet is of variable quality and is not subject to regulation. Many sources of information contain advice on therapies that have no evidence base and may put patients at risk. It is important that researchers and health care providers be aware of the content and quality of this information so as to offer advice to patients about the evidence and potential risks of CAM therapies. This can only be achieved by increasing awareness among ophthalmologists of the range of products and quality of information available for CAM therapies for glaucoma.

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