• Michael Levy, Diane Heels-Ansdell, Rajesh Hiralal, Mohit Bhandari, Gordon Guyatt, Salim Yusuf, Deborah Cook, Juan Carlos Villar, Matthew McQueen, Edward McFalls, Miodrag Filipovic, Holger Schünemann, John Sear, Pierre Foex, Wendy Lim, Giora Landesberg, Gilles Godet, Don Poldermans, Francesca Bursi, Miklos D Kertai, Neera Bhatnagar, and P J Devereaux.
• Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
• Anesthesiology. 2011 Apr 1;114(4):796-806.

BackgroundThere is uncertainty regarding the prognostic value of troponin and creatine kinase muscle and brain isoenzyme measurements after noncardiac surgery.MethodsThe current study undertook a systematic review and meta-analysis. The study used six search strategies and included noncardiac surgery studies that provided data from a multivariable analysis assessing whether a postoperative troponin or creatine kinase muscle and brain isoenzyme measurement was an independent predictor of mortality or a major cardiovascular event. Independent investigators determined study eligibility and abstracted data in duplicate.ResultsFourteen studies, enrolling 3,318 patients and 459 deaths, demonstrated that an increased troponin measurement after surgery was an independent predictor of mortality (odds ratio [OR] 3.4, 95% confidence interval [CI] 2.2-5.2), but there was substantial heterogeneity (I(2) = 56%). The independent prognostic capabilities of an increased troponin value after surgery in the 10 studies that assessed intermediate-term (≤ 12 months) mortality was an OR = 6.7 (95% CI 4.1-10.9, I(2) = 0%) and in the 4 studies that assessed long-term (more than 12 months) mortality was an OR = 1.8 (95% CI 1.4-2.3, I(2) = 0%; P < 0.001 for test of interaction). Four studies, including 1,165 patients and 202 deaths, demonstrated an independent association between an increased creatine kinase muscle and brain isoenzyme measurement after surgery and mortality (OR 2.5, 95% CI 1.5-4.0, I(2) = 4%).ConclusionsAn increased troponin measurement after surgery is an independent predictor of mortality, particularly within the first year; limited data suggest an increased creatine kinase muscle and brain isoenzyme measurement also predicts subsequent mortality. Monitoring troponin measurements after noncardiac surgery may allow physicians to better risk stratify and manage their patients.

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