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Statistics in medicine · Aug 2006
Sample size estimation for the van Elteren test--a stratified Wilcoxon-Mann-Whitney test.
- Yan D Zhao.
- Lilly Research Laboratories, Eli Lilly & Company, Indianapolis, IN 46285, USA. yzhao@lilly.com
- Stat Med. 2006 Aug 15;25(15):2675-87.
AbstractThe van Elteren test is a type of stratified Wilcoxon-Mann-Whitney test for comparing two treatments accounting for strata. In this paper, we study sample size estimation methods for the asymptotic version of the van Elteren test, assuming that the stratum fractions (ratios of each stratum size to the total sample size) and the treatment fractions (ratios of each treatment size to the stratum size) are known in the study design. In particular, we develop three large-sample sample size estimation methods and present a real data example to illustrate the necessary information in the study design phase in order to apply the methods. Simulation studies are conducted to compare the performance of the methods and recommendations are made for method choice. Finally, sample size estimation for the van Elteren test when the stratum fractions are unknown is also discussed.Copyright 2006 John Wiley & Sons, Ltd.
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