• Journal of neurotrauma · Jun 2006

    Intrathecal and systemic concentration of NT-proBNP in patients with severe traumatic brain injury.

    • Chlodwig Kirchhoff, Julia Stegmaier, Viktoria Bogner, Sonja Buhmann, Thomas Mussack, Uwe Kreimeier, Wolf Mutschler, and Peter Biberthaler.
    • Chirurgische Klinik und Poliklinik, Klinikum Innenstadt, Ludwig-Maximilians-Universitaet, Munich, Germany. Chlodwig.Kirchhoff@med.uni-muenchen.de
    • J. Neurotrauma. 2006 Jun 1;23(6):943-9.

    AbstractOutcome of patients suffering from traumatic brain injury (TBI) depends on the development of secondary brain damage. In this context, recent studies underlined the role of the natriuretic peptides- atrial natriuretic peptide and brain natriuretic peptide (BNP)-in aneurysmatic subarachnoidal hemorrhage (SAH). Especially BNP correlates with intracranial pressure and clinical outcome after SAH. Since its role in TBI remains unclear, the intracranial and systemic concentrations of N-terminal (NT)-proBNP were analyzed in patients suffering from severe TBI. We measured NT-proBNP levels in cerebrospinal fluid (CSF) and serum of 14 patients suffering from severe TBI (GCS15 mm Hg (n=6), the serum (800+/-150 pg/mL) and CSF levels (55+/-9 pg/mL) of NT-proBNP were significantly increased after 24 h, as compared to patients with ICP15 mm Hg. Further studies are currently performed to elucidate the physiologic role of NT-proBNP in TBI.

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